*Note: All data is from the 1985 tournament to the present.

Know your seed
No. 1 No. 9
No. 2 No. 10
No. 3 No. 11
No. 4 No. 12
No. 5 No. 13
No. 6 No. 14
No. 7 No. 15
No. 8 No. 16
Probably the most volatile seed in all of college basketball, the No. 12 seed has wreaked havoc on No. 5 seeds and brackets alike for years. In 27 of the last 31 years, the 12 seed has won at least one first round game for a total record of 44-50 (35.48 percent) against the 5 seed. The only exceptions were in 1988, 2000, 2007 and 2015.

The average margin for 5 vs. 12 seeds is only 4.1 points, and the lower seed is 17-26 in games decided by four points or less.

Read: Why we need to pick more 12-5 upsets
 

While over 50 percent of the 12-seed who won in the first round fail to advance past the second round, 18 of the 44 teams made it it to Sweet 16.

DePaul got the ball rolling in 1986 after beating Virginia by four in opening round, and North Dakota State was the last 12 seed to advance to the Sweet 16 in 2014. Eastern Michigan’s 20-point win over Mississippi State in 1991 still stands as the largest victory by a 12 seed over a 5 seed.

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Missouri is the only program to make it to the Elite Eight as a 12 seed. In 2002, the Tigers’ run through the West regional bracket began with a 93-80 win over fifth-seeded Miami (Fla.). That game featured a ferocious Tiger squad where six players -- including the entire starting lineup -- eclipsed double-digits in points. Led by senior guard Clarence Gilbert, Missouri raced out to an eight-point halftime lead and tacked on a few more for the 13-point upset victory.

The Tigers went on to upset fourth-seeded Ohio State and eighth-seeded UCLA before falling in the Elite Eight to second-seeded Oklahoma.

Utah State, who has been the No. 12 seed a record five times, is only 1-4 against No. 5 seeds. Its lone win came in 2001 against Ohio State.

Year Winner Loser Score
2000 Connecticut Utah State 75-67
2001 Utah State Ohio State 77-68
2006 Washington Utah State 75-61
2010 Texas A&M Utah State 69-53
2011 Kansas State Utah State 73-68

Eastern Michigan offered the biggest surprise in the first round, as the Eagles beat Mississippi State, 76-56, on March 15, 1991.

Sources: Washington Post tournament database, Sports-reference.com, NCAA Record Book