*Note: All data is from the 1985 tournament to the present.

Know your seed
No. 1 No. 9
No. 2 No. 10
No. 3 No. 11
No. 4 No. 12
No. 5 No. 13
No. 6 No. 14
No. 7 No. 15
No. 8 No. 16
The 1997 Arizona Wildcats became the first team in the 64-team format to defeat three No. 1 seeds en route to the national championship. As tough it was to defeat Kansas, North Carolina and Kentucky, the Wildcats faced a tough opponent in No. 13 seed South Alabama to start their tournament run. Arizona had to overcome a 10-point deficit before it eventually closed on a 22-4 run to beat South Alabama, 65-57.

The number of highly contested games between the No. 4 and No. 13 seeds have grown. Although the top seed has a .798 winning percentage, the average margin has only been nine or so points in favor of the fourth-seeded teams. Additionally in the past 16 years, all four-seeds have moved out of the first round just five times.

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La Salle, Oklahoma, San Diego State and Xavier have the distinction of being the only four programs to play in the opening 4-v-13 game as both seeds. The Musketeers and Explorers both have won as a No. 4 and a No. 13 seed, while the Sooners have two victories as each under their belt.

School Year as No. 4 Year as No. 13
La Salle 1990 1988, 1992, 2013, 
Oklahoma 1986, 1992, 1995, 2001 1999
San Diego State 1985, 2002 2014
Xavier 1987 2009

Louisville owns the most appearances as a No. 4 seed, four more than any other program. The Cardinals maintain an 8-1 first-round record, with the lone loss in a 2011 thriller to Murray State. Two of Louisville's wins were by 19 points and 22 points but the rest were decided by single-digits including a two-point win over UC Irvine in 2015.