If there’s one thing the NCAA Tournament is known for, it’s, well, madness. When the first round begins, 64 teams enter and less than a month later, only one will walk out as a champion.

BRACKET CHALLENGE GAME

The Madness is underway.
CHECK YOUR BRACKET
What does this mean? Upsets. Lots, and lots, of upsets.

That’s nothing new. If anything, upsets are synonymous with the month of March. But where are those upsets most likely to occur?

Other than 2011, when the Southeast and Southwest regionals made a one-time appearance, we’ve had the same four regionals for the past 10 years: East, West, South and Midwest. And looking at the tournament history for those past 10 years gives us some interesting insights.

RELATED: How do seeds perform in the Final Four?

For starters, if you’re a top-ranked team, cross your fingers that you don’t end up in the Midwest. Over the past 10 years, one third of all games in the Midwest regional have been upsets (any lower-ranked team defeating a higher-ranked team) — the most of any regional. What's more, just over a fifth of games (20.7 percent) have been major upsets (an upset with a seed differential of five or more).

  East West South Midwest
 

Total upsets

(Major upsets)

Total upsets

(Major upsets)

Total upsets

(Major upsets)

Total upsets

(Major upsets)

2016 4 (2) 4 (2) 4 (2) 7 (5)
2015 5 (3) 2 (1) 3 (2) 2 (1)
2014 5 (2) 3 (1) 7 (4) 5 (4)
2013 5 (1) 8 (5) 5 (3) 2 (2)
2012 2 (0) 4 (1) 4 (3) 7 (4)
2011 4 (2) 3 (0) N/A N/A
2010 7 (4) 4 (1) 3 (2) 6 (2)
2009 3 (1) 4 (0) 2 (1) 6 (3)
2008 2 (0) 4 (3) 1 (0) 6 (5)
2007 4 (0) 2 (1) 2 (0) 4 (2)
TOTAL 41 (15) 38 (15) 31 (17) 45 (28)
TOTAL % 27.3% (10%) 25.3% (10%) 23% (12.6%) 33.3% (20.7%)

On the flip side is the South regional, where only 23 percent of the 135 games in the past 10 years have been upsets — the least among all regionals.

The next bit of information seems to follow naturally, then. Six of the past 10 national champions (and two of the runners-up) have come out of the South regional. 

  Champion Regional
2016 Villanova South
2015 Duke South
2014 Connecticut East
2013 Louisville Midwest
2012 Kentucky South
2011 Connecticut West
2010 Duke South
2009 North Carolina South
2008 Kansas Midwest
2007 Florida  South

The craziest any regional has gotten in the past 10 years was in 2013, when the West saw eight upsets in its 15 games. No. 12 seed Mississippi, No. 13 seed La Salle and No. 14 seed Harvard all wreaked havoc on brackets by pulling off first-round wins. In the Round of 32, No. 9 seed Wichita State took down AP No. 1 Gonzaga, then punched its ticket to the Final Four with a 70-66 win over No. 2 Ohio State in the Elite Eight.

RELATED: History shows AP No. 1 is far from a championship lock

That year was one of three that saw five major upsets in one regional. The other two were in 2016 and 2008, both in the Midwest regional. Last year's Midwest saw No. 15 seed Middle Tennessee shock No. 2 seed Michigan State and Syracuse become the first No. 10 seed to ever reach the Final Four. In 2008, the Midwest regional was the stage upon which a little-known guard named Steph Curry took his No. 10 seed Davidson Wildcats all the way to the Elite Eight.

But as fun as upsets are, a perfect regional is also something to marvel at. The closest we've come in the past 10 years was in 2008's South regional, where the only upset of its 15 games came when No. 5 seed Michigan State took down No. 4 seed Pittsburgh 65-54 in the Round of 32. Thrilling.

In the end, does the name of the regional a team ends up in really have any bearing on their fate? Probably not. But if there's one thing the NCAA Tournament has taught us, it's that probablys matter little in March.