No. 2 Oregon throttles Virginia 59-10

CHARLOTTESVILLE, Va. -- De'Anthony Thomas ran for 124 yards and three touchdowns, Marcus Mariota threw for two touchdowns and ran 71 yards for another score and No. 2 Oregon started fast and manhandled Virginia 59-10 on Saturday.

The Ducks (2-0), who gained a school-record 772 yards last week in beating Nicholls State, looked capable of doing it again against a Virginia defense that hoped to keep the Cavaliers in the game. Oregon finished with 557 yards and did all its scoring while possessing the ball for just 21:25.

Virginia (1-1) got a very early look at what it was up against as Mariota dropped back on a third-and-5 in the game's opening series, then bolted up the middle untouched, going 71 yards for a touchdown.

After 1:51, the Ducks were on their way to their 16th consecutive victory on their opponent's field, the longest streak in the country.

Guiton to the rescue for No. 3 Ohio State in 42-7 win

COLUMBUS, Ohio -- Kenny Guiton took over when Braxton Miller left with a sprained left knee, running for one touchdown and passing for two on Saturday while leading No. 3 Ohio State to a 42-7 victory against San Diego State.

Miller watched the last three quarters from the sideline after being sandwiched between two tacklers on the Buckeyes' seventh offensive play. The Buckeyes (2-0) didn't need him.

Guiton, who helped save Ohio State's 12-0 season a year ago, had the most playing time he's ever had in a game. He set career bests with 19 of 28 passing for 152 yards and 83 rushing yards.

It was another disappointing outing for the Aztecs (0-2), who lost 40-19 to FCS Eastern Illinois at home in their opener.

No. 4 Clemson, Boyd power past SC State 52-13

CLEMSON, S.C. -- Tajh Boyd ran for a touchdown and No. 4 Clemson returned two interceptions for scores for the first time in program history in a 52-13 victory against FCS opponent South Carolina State on Saturday.

Boyd accounted for five TDs a week ago and became a prime Heisman Trophy contender as the Tigers (2-0) defeated No. 11 Georgia 38-35.

In this one, Boyd scored Clemson's first touchdown and played only a half against the Bulldogs (0-2) before finding a spot on the Death Valley sidelines next to offensive coordinator Chad Morris. That was more than enough, though, for Clemson to move to 27-0 all-time against FCS teams.

Cornerbacks Martin Jenkins and Darius Robinson each had pick-6 scores to help the Tigers to a 38-7 lead by halftime.

No. 5 Stanford opens with 34-13 win against San Jose State

STANFORD, Calif. -- Tyler Gaffney ran for 104 yards and two touchdowns in an impressive return after playing baseball in the minors last year, leading No. 5 Stanford past gritty San Jose State 34-13 on Saturday night in its season opener.

With career-rushing leader Stepfan Taylor in the NFL now, Gaffney made sure the defending Pac-12 and Rose Bowl champions kept the ground game going strong. The Cardinal scored on their first three possessions and forced prolific passer David Fales to toss short passes for little gain.

Kevin Hogan threw for 207 yards and two touchdowns for Stanford in front of an announced sellout crowd of 50,424 -- the largest since 50,425 showed up for Southern California in 2008. Stanford has won nine consecutive games.

Murray, Gurley lead No. 11 Georgia past sixth-ranked South Carolina

ATHENS, Ga. -- Aaron Murray threw for 309 yards and four touchdowns, Georgia's beleaguered defense finally came up with a stop, and the 11th-ranked Bulldogs defeated No. 6 South Carolina 41-30 on Saturday for an early edge in the Southeastern Conference East.

Coming off a 38-35 loss at Clemson, Georgia could not afford another defeat if it wanted to remain a serious contender for a national title.

Murray took care of that, turning in one of the best games of his career and shaking off his reputation as a quarterback who couldn't win the big game. The fifth-year senior capped his stellar day for the Bulldogs (1-1, 1-0 SEC) with an 85-yard touchdown pass to Justin Scott-Wesley with 13 minutes remaining.

The defense made sure it stood up, stuffing Mike Davis on fourth-and-goal from inside the 1.

Davis led the Gamecocks (1-1, 0-1) with 149 yards rushing on 16 carries.

Manziel leads No. 7 Texas A&M to 65-28 win against Sam Houston State

COLLEGE STATION, Texas -- Johnny Manziel threw for 426 yards and three touchdowns and ran for another score in less than three quarters to give No. 7 Texas A&M to a 65-28 win against Sam Houston State on Saturday night.

The 2012 Heisman Trophy winner played about a quarter more than he did last week when he sat out the first half serving a suspension for what the school called an "inadvertent'' violation of NCAA rules involving signing autographs.

Texas A&M's suspension-depleted defense was burned for several big plays by the Bearkats, the FCS runner-up the past two seasons, in the final tuneup before next week's rematch with top-ranked Alabama.

Sam Houston's Timothy Flanders had 170 yards rushing with two scores and added a touchdown reception.

Texas A&M's Mike Evans had a career-high 155 yards receiving, Tra Carson ran for 51 with two touchdowns and Ben Malena had 68 yards rushing and a score.

No. 8 Louisville routs Eastern Kentucky 44-7

LOUISVILLE, Ky. -- Teddy Bridgewater threw for 397 yards and four touchdowns, and Louisville routed Eastern Kentucky 44-7 on Saturday on a day the Cardinals' defense just missed a shutout for a second consecutive week.

Linebacker Preston Brown had two of Louisville's four sacks, and Calvin Pryor had an interception as Louisville limited Eastern Kentucky to 76 yards of offense in the first half.

The Cardinals (2-0) needed the defensive plays. Following the noon kickoff, Louisville settled for a pair of field goals from John Wallace after turnovers gave the offense short fields. The Cardinals also settled for a third field goal in the third quarter despite reaching Eastern Kentucky's 4.

Bridgewater hit his first five passes to continue his strong start on his season and Heisman Trophy candidacy. He tossed TD passes to Damian Copeland and Gerald Christian, and two to DeVante Parker while connecting with eight different receivers. He wound up 23 of 32 with no interceptions after throwing for five touchdowns with one interception in the opener.

No. 9 LSU airs it out in 56-17 win against Ala.-Birmingham

BATON ROUGE, La. -- Zach Mettenberger passed for an LSU single-game record five touchdowns, receiver Odell Beckham Jr. scored one of his four touchdowns on a 100-yard field goal return, and the ninth-ranked Tigers overwhelmed UAB 56-17 on Saturday night.

LSU coach Les Miles also decided to end running back Jeremy Hill's benching in the second quarter of the second game of the season.

Mettenberger finished 16 of 19 for 282 yards and was not intercepted. Beckham's 136 yards and three TDs receiving were both career highs. He led LSU (2-0) with 331 all-purpose yards.

Darren Reaves and Jamarcus Nelson each had touchdowns in the first half for UAB (0-2).

Miami knocks off No. 12 Florida 21-16

MIAMI GARDENS, Fla. -- Stephen Morris threw two first-quarter touchdown passes, and Miami took advantage of Florida giving the ball away on four red-zone opportunities on the way to knocking off the 12th-ranked Gators 21-16 on Saturday.

Duke Johnson added a 2-yard touchdown run with 3:29 left to make it 21-9 Miami (2-0), which has won four consecutive games for the first time since 2008 and will almost certainly return to the AP Top 25 on Sunday for the first time since 2010.

Jeff Driskel threw for a career-best 291 yards and had a 21-yard touchdown pass to Solomon Patton with 2:08 left for the Gators (1-1), who lost three fumbles, had two passes intercepted and were stopped once on downs. Driskel also ran for a touchdown.

But Driskel also turned the ball over twice in the fourth quarter, getting intercepted -- one of Florida's many red-zone miscues -- by Miami's Tracy Howard with 6:41 left, then getting hit deep in Florida territory and fumbling it away about two minutes later to set up the score by Johnson.

Walsh, No. 13 Oklahoma State beats UTSA 56-35

SAN ANTONIO -- New starter J.W. Walsh completed his first 10 passes, finished 24 of 27 for 326 yards and four touchdown throws as No. 13 Oklahoma State beat UTSA 56-35 on Saturday.

It's the fourth start for the sophomore Walsh, his first this season after a quick relief performance for Clint Chelf last week. With his speedy start against a Roadrunners team entering its third season of football, Walsh led the Cowboys (2-0) to touchdowns on five of six first-half possessions.

UTSA (1-1) tied the score 7-7 when Kenny Bias scored on a 6-yard run with 4:22 left in the first quarter. But Walsh scored from 4 yards out in the second quarter and the Cowboys led 35-7 at halftime.

Hill leads BYU to 40-21 win against No. 15 Texas

PROVO, Utah -- Taysom Hill led a big night on the ground for BYU, rushing for 259 yards -- second-most in school history -- and three touchdowns to help the Cougars beat up No. 15 Texas 40-21 on Saturday night.

Hill was masterful in guiding the team's new read-option offense as the Cougars (1-1) rolled up 550 yards rushing, eclipsing a 55-year-old team record. It was also the most yards rushing Texas (1-1) has ever allowed, and brought back memories of last season's myriad defensive failures by the Longhorns.

The elusive Hill scored on runs of 68, 20 and 26 yards. He came close to breaking BYU's single-game rushing record of 272 yards, a mark set by quarterback Eldon Fortie in 1962.

Clay paces No. 16 Oklahoma past West Virginia 16-7

NORMAN, Okla. -- Brennan Clay helped Oklahoma overcome its spotty passing game.

The senior running back had a career-high 170 yards rushing as Oklahoma switched quarterbacks in the second half and still beat West Virginia 16-7 on Saturday night.

The No. 16 Sooners (2-0, 1-0 Big 12) scored the game's final 16 points after trailing 7-0 in the first quarter. Freshman quarterback Trevor Knight threw a pair of third-quarter interceptions, leading to junior Blake Bell taking over in the fourth quarter.

Clay finished with 22 carries, leading an Oklahoma offense that had 316 yards rushing and topping his previous best of 157 yards rushing against Iowa State in 2012.

Paul Millard was 21-of-42 passing for 218 yards for the Mountaineers (1-1, 0-1), whose lone score came on a 75-yard touchdown run by Dreamius Smith in the first quarter.

No. 17 Michigan beats No. 14 Notre Dame 41-30

ANN ARBOR, Mich. -- Devin Gardner threw four touchdown passes, including a victory-sealing connection to Drew Dileo with 4:18 left, and Gardner, a dual-threat quarterback wearing No. 98 to honor Tom Harmon, ran for a score to lead No. 17 Michigan to a 41-30 win against No. 14 Notre Dame on Saturday night in front of an NCAA-record crowd of 115,109.

The Wolverines (2-0) had a pair of 14-point leads, but the Fighting Irish (1-1) refused to get routed.

Notre Dame pulled within a TD early in the fourth quarter when defensive end Stephon Tuitt made a diving interception in the end zone. Kyle Brindza made a 40-yard field goal with 9:15 left to pull Notre Dame within four points.

The Irish were called for pass interference twice on the ensuing drive and Gardner later took advantage with a 4-yard touchdown to Dileo.

Tommy Rees threw a second interception with 1:29 left.

QBs Siemian, Colter lead No. 19 Northwestern

EVANSTON, Ill. -- Trevor Siemian threw for 259 yards and a career-high three touchdowns, Kain Colter passed for a touchdown and ran for one, and No. 19 Northwestern pounded Syracuse 48-27 on Saturday.

Tony Jones added a personal-best 185 yards receiving and a 47-yard TD, and the Wildcats (2-0) racked up 581 yards in all. They also intercepted Syracuse's Drew Allen four times on the way to an easy victory.

How easy?

They scored the game's first 20 points and led 34-7 at the half after collecting 387 yards, with their quarterbacks picking apart Syracuse (0-2).

They each completed 11 of 12 passes in the first half, and Colter was fine after suffering a concussion early in last week's win at California.

No. 21 Wisconsin shuts down Tennessee Tech 48-0

MADISON, Wis. -- No.21 Wisconsin tossed a shutout on defense and had three backs for more than 100 yards for a second consecutive game -- including 140 yards and a 37-yard score for Melvin Gordon -- in a 48-0 rout Saturday of FCS school Tennessee Tech.

A week after opening head coach Gary Andersen's tenure in Madison with a 45-0 drubbing of Massachusetts, the Badgers bounced back with an equally impressive victory against thoroughly overmatched Tennessee Tech. Wisconsin has back-to-back shutouts to open a season for the first time since holding Miami and Marquette scoreless in 1958.

James White added 109 yards rushing on 22 carries, while freshman Corey Clement had 149 on 13 carries in the second half.

Joel Stave was 24 of 29 for 219 yards with three touchdowns and an interception. Defensive back Darius Hillary set the tone early by forcing the fumble recovered by Dezmen Southward on the first play from scrimmage for the Badgers (2-0).

No. 22 Nebraska starts fast, beats Southern Miss 56-13

LINCOLN, Neb. -- Stanley Jean-Baptiste and Ciante Evans returned first-quarter interceptions for touchdowns and No. 22 Nebraska made quick work of Southern Mississippi in a 56-13 victory Saturday.

Taylor Martinez threw for three touchdowns and Ameer Abdullah ran for two more for the Cornhuskers (2-0), who now turn their attention to next week's home game against No. 18 UCLA.

Jean-Baptiste jumped in front of Rickey Bradley Jr. just as Allan Bridgford's pass arrived on the third play of the game and ran it back 43 yards.

Evans put the Huskers up 21-3 with the first of his two interceptions, catching a ball tipped by Tyre'oune Holmes and going 22 yards to the end zone.

It was a solid rebound for a Nebraska defense that surrendered 602 yards in a 37-34 win against Wyoming last week.

The Golden Eagles (0-2) lost their 14th in a row, the longest losing streak in the FBS.

No. 23 Baylor rolls to 70-13 win against Buffalo

WACO, Texas -- Bryce Petty threw for 338 yards and two touchdowns, Lache Seastrunk ran for 150 yards with three scores and Baylor's first-team offense had 576 total yards in only 11 minutes with the ball as the 23rd-ranked Bears beat Buffalo 70-13 on Saturday.

The starters for the Bears (2-0) had eight touchdowns in their nine drives. The only non-scoring driving was when they had the ball at the end of the first half.

Baylor finished with a school-record 781 total yards and topped the 69 points scored a week earlier in what had been the most for the Bears since 1929.

Alex Neutz had six catches for a career-high 197 for Buffalo (0-2).

Boykin leads No. 24 TCU after Pachall's injury

FORT WORTH, Texas -- Trevone Boykin led three consecutive scoring drives after Casey Pachall left with an injury, and the No. 24 TCU pulled away from Southeastern Louisiana 38-17 on Saturday.

While Pachall walked slowly to the locker room, Boykin ran 16 yards on the next play, and Jaden Oberkrom ended the first half with a 46-yard field goal that put the Horned Frogs (1-1) ahead 17-14.

Boykin completed a 29-yard pass to Brandon Carter on the first play of the second half, and Carter finished that drive with a 5-yard scoring run. Then Boykin threw 27 yards to Josh Doctson for a 31-14 lead.

Late FG lifts Washington State past No. 25 USC 10-7

LOS ANGELES -- Andrew Furney kicked a 41-yard field goal with 3:03 to play, and Washington State beat No. 25 Southern California 10-7 on Saturday night for its first victory at the Coliseum in 13 years.

Damante Horton returned an interception 70 yards for a tying score in the final seconds of the first half for Washington State (1-1, 1-0 Pac-12), and he made the clinching interception with 2:18 to play in the Cougars' first win against the Trojans anywhere since 2002.

Dom Williams took Connor Halliday's third-and-long screen pass 49 yards to the USC 30 with 5 1/2 minutes left to set up Furney's tiebreaking kick.

Horton then picked off Max Wittek's pass to finish off USC (1-1, 0-1), which received loud boos throughout its Pac-12 opener.