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No. 15 Cal State Fullerton at No. 5 TCU

The Horned Frogs and Titans will meet for the fourth consecutive season, and pitching will undoubtedly headline the weekend series. Unbeaten TCU enters the weekend with a 1.32 ERA, while the Titans will try to improve their 2-2 mark with some stellar pitching of their own. Friday will feature Fullerton right-hander Noe Ramirez (1-0, 1.29 ERA) and TCU right-hander Kyle Winkler (1-0, 0.00 ERA) in a battle of Preseason All-America selections. Ramirez struck out five in seven innings against Long Beach State, while Winkler tossed a one-hitter in his opener against Kansas. TCU leads the series 5-4 in the last three seasons, but Fullerton has the overall advantage, 8-5.

• Schedule: Feb. 25 6:30 p.m. CT; Feb. 26 2 p.m. CT; Feb. 27 1 p.m. CT

No. 12 Stanford at No. 3 Vanderbilt

In a match-up between nationally-ranking opponents this weekend No. 12 Stanford heads to Nashville, Tenn., for a showdown with No. 3 Vanderbilt beginning Friday. Stanford opened the season on the road taking two of three games at Rice, and then topped No. 30 California in a midweek contest to move to 3-1. After a four-game sweep against San Diego teams last weekend, the Commodores downed Belmont 6-2 on Wednesday. Friday night’s contest is slated to feature Stanford sophomore right-hander Mark Appel (0-0, 3.18 ERA), while ace right-hander Sonny Gray (1-0, 6.23 ERA) will take the mound for Vandy. Both pitchers received preseason All-America honors by various publications. Stanford leads the series 3-1, including two wins in a three-game series in Palo Alto in 2009.

• Schedule: Feb. 25 4 p.m. CT; Feb. 26 at 2 p.m. CT; Feb. 27 at 1 p.m. CT

Baylor at Georgia

The Bears hit the road for the first time this season, heading to Athens, Ga., for a three-game series at Georgia. After winning last weekend’s series against Oral Roberts, the Bears fell 2-0 to TCU on Tuesday. Georgia was swept by Stetson to open the season, but bounced back with a midweek win against Furman. Both teams will be looking to gain some ground nationally in this Big 12-SEC match-up. The series is tied at 1-1 after two meetings in the 2010 QTI Powers Opening Weekend Classic.

• Schedule: Feb. 25 5 p.m. ET; Feb. 26 2 p.m. ET; Feb. 27 1 p.m. ET

East Carolina at No. 10 Virginia

After posting a pair of shutouts against Youngstown State last weekend, the Pirates will bring their pitching talents to Charlottesville to take on Atlantic Coast Conference foe Virginia. The Cavaliers cruised through the Auburn Tournament last weekend, and picked up a midweek victory against VMI. ECU gave up just three runs against the Penguins, compiling a 1.00 ERA with 25 strikeouts and just six walks on the weekend. RHP Seth Maness (1-0, 1.29 ERA) and junior left-hander Danny Hultzen (1-0, 1.34 ERA) will tangle in this match-up of unbeatens. Maness has 29 career victories, which ranks fourth in Conference USA history.

• Schedule: Feb. 25 5 p.m. ET; Feb. 26 2 p.m. ET; Feb. 27 1 p.m. ET

St. John’s at No. 24 Georgia Tech

The Red Storm will try to build on a successful opening weekend at the BIG EAST-Big Ten Challenge after winning their first two games before dropping an 8-7 loss to Ohio State in 11 innings. Sophomore Jeremy Baltz, the 2010 National Freshman of the Year, batted .500 with seven RBI in to lead St. John’s. The Yellow Jackets enter the weekend 3-2, and boast the second best ERA in the ACC at 2.22. The two squads are meeting for the first time since 1991. The series is tied 1-1.

• Schedule: Feb. 25 4 p.m. ET; Feb. 26 2 p.m. ET; Feb. 27 1 p.m. ET