NASHVILLE, Tenn. -- Mike Yastrzemski homered and drove in four runs and Vanderbilt beat Oregon State 11-1 Friday night in the opener of a best-of-three NCAA super regional series.

Yastrzemski, the grandson of former Boston Red Sox star Carl Yastrzemski, was 2 for 4 and his three-run home run in the fourth gave Vanderbilt (51-10) an eight-run lead. Jason Esposito added a two-run home run and drove in three runs.

The Commodores scored 10 of their runs with two outs.

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Vandy ace Sonny Gray (12-3), allowed one run on four hits in 6.2 innings four days after he was drafted 18th overall by the Oakland Athletics.

Jake Rodriguez had three hits and drove in the only run for Oregon State (41-18).

Beavers starter Sam Gaviglio (12-3) gave up 10 earned runs on 10 hits in 5.1 innings.

Vanderbilt is just one win away from its first trip to the College World Series. Oregon State will need to win two in a row to reach its first CWS since winning back-to-back national championships in 2006-07.

Vanderbilt jumped on Gaviglio early. After two quick outs in the bottom of the first inning, Gaviglio walked three and allowed three punishing singles. Yastrzemski and Esposito each drove in a run and Connor Harrell knocked in a pair with a hit through the right side of the infield.

Gaviglio, who threw 136 pitches in a complete game against Creighton in last weekend’s regional, got into trouble again in the fourth. After Gaviglio gave up back-to-back singles and a walk, Curt Casali knocked in a run on a groundout. That brought up Yastrzemski with two outs and the right fielder homered over the right-field wall on the first pitch.

Gray, meanwhile, stayed sharp. He retired the first seven batters and gave up one hit through five innings.

He worked out of a jam in the fifth, leaving runners stranded on the corners after striking out Brian Stamps. Gray finished with four strikeouts. He spent most of the night throwing above 90 mph. The stadium radar gun clocked him at 100 when Andrew Susac chased a high fastball in the fourth inning.

Reliever Corey Williams pitched the last 2.1 innings, retiring all seven batters he faced.