Ware became Louisville's rallying point on the way to the national title after he broke his leg in a win against Duke in the finals of the Midwest Regional last season.
He had a rod inserted in the leg and tried to come back this season. But he averaged 1.7 points in nine games and eventually took a medical redshirt.
He wasn't seen with the team during the past several weeks. On Saturday, the day after Louisville's season ended with a loss to Kentucky, the junior from the Atlanta area announced his decision.
''We wish Kevin Godspeed,'' head coach Rick Pitino said.