Athletic director Mike Hamrick announced D'Antoni's hiring Thursday. D'Antoni is a 1970 Marshall graduate.
The 66-year-old D'Antoni is the older brother of Lakers head coach Mike D'Antoni. He spent the past two seasons on the Lakers' staff and has had stints as an assistant with the Phoenix Suns and New York Knicks.
D'Antoni spent 30 years as head coach at Socastee High School in Myrtle Beach, S.C., before leaving in 2005.
D'Antoni replaces Tom Herrion, who resigned last month after an 11-22 season.
• Herrion resigns as Marshall head coach