It isn't clear when Major will return to coaching.
The school wouldn't specify the nature of the health issues Friday citing privacy concerns, but Major says in a press release ''my family has a history of heart and eye issues, and I plan to have procedures done over the next couple of months to address them.''
Major has spent the past four seasons at Charlotte. The 49ers won 21 games in 2013-14, their first 20-win season since 2007-08.
Athletic director Judy Rose says ''there is never an easy or good time for a coach to be away from his team, so this has been a very difficult decision for Alan.''