The only two Final Fours that haven't featured a No. 1 seed eventually crowned a No. 3 seed as the champion. The 2006 Florida Gators and the 2011 Connecticut Huskies hold that distinction and both won their opening round against the No. 14 seed by more than 25 points.
Overall, the No. 3 seed is 111-21 in the first round. Only six No. 3 seeds in the past 10 years have failed to advance to the second round, with a pair losing in the same year for the first time since 1986 in the 2015 tournament. West Virginia’s stunning upset at the hands of Stephen F. Austin in 2016 marked the fourth consecutive tournament where at least one No. 3 suffered an upset. All four No. 3 seeds won their opening game last season by an average margin of 14.25 points.
Michigan needed extra time to defeat fellow No. 3 seed Seton Hall in the 1989 championship game. The Wolverines came away with a 80-79 victory thanks to clutch free throws made by Rumael Robinson in the final seconds. Syracuse defeated Kansas in the 2003 national championship behind the stellar 20-point, 10-rebound performance by some guy named Carmelo Anthony.
One of the lowest scoring first round games in tournament history occurred between No. 3 Kansas and No. 14 Ohio in the 1985 tournament. While the Jayhawks won by 11, the teams combined for only 87 points. Since that game, 1995 Purdue is the only other No. 3 seed that has failed to score at least 50 against a No. 14 seed.